The MECUD interactive dashboard provides a transparent, data-driven view of the region's growing role in discovering undiagnosed diseases. It effectively visualises patient demographics, diagnostic yield, sequencing progress, and country representation, while also showing trends over time.

By integrating with seqr's variant-tracking infrastructure, the dashboard demonstrates how cases progress from "unsolved" to "resolved," thanks to ongoing reanalysis and Variant-Level Matching (VLM). Furthermore, linking to GenomeConnect's patient registry allows MECUD to share anonymised insights into variant reclassification outcomes. This creates a learning ecosystem that links clinical practice, research, and patient involvement.

MECUD's network spans across the Middle East and North Africa region, establishing collaborative partnerships with leading medical institutions and research centers. The map below illustrates our current active recruitment centers and partner institutions across multiple countries, demonstrating the extensive reach of our genomic research initiative.

This section outlines the methodology by which clinicians, participants, and partner institutions can participate in MECUD's genomic workflow. Patients who meet the specified inclusion criteria will undergo a digital consent process modeled after GenomeConnect, which allows the secure use of their data for future research reanalysis.

Samples, including DNA, RNA, plasma, or fibroblasts, collected at partner institutions will be barcoded, carefully documented, and sent to the sequencing hub in Dubai, following standardised protocols.

Data analysis will use MECUD's AI-assisted pipelines and will be incorporated into seqr for variant prioritisation and automated reanalysis. This structured approach effectively addresses ongoing regional issues of fragmented workflows, limited data reuse, and inconsistent infrastructure, thus creating a unified cross-border pipeline that supports patient recruitment, diagnosis, and discovery.

Each partner centre acts as a national hub for clinical recruitment, sample processing, and data contribution within the distributed framework of MECUD. Through direct integration with Seqr and GenomeConnect, local researchers gain access to variant curation tools, data-sharing infrastructure, and training resources that meet international standards.

Patients enrolled at these centres can securely share updates and new medical information, thereby improving the long-term quality of data and the accuracy of variant interpretation. This network includes the United Arab Emirates, Saudi Arabia, Kuwait, Qatar, Jordan, Lebanon, Egypt, Turkey, Iraq, and Yemen, establishing the region's first interconnected genomic and clinical network capable of facilitating real-time collaboration and discovery.

MECUD is dedicated to fostering collaboration with academic institutions, healthcare systems, and industry innovators to advance research on undiagnosed diseases across the Middle East and North Africa. By establishing partnerships with ClinGen, seqr, and GenomeConnect, MECUD has created a comprehensive framework for secure data sharing, automation of reanalysis processes, and international interoperability.

Each partnership operates within governance frameworks compliant with UAE regulations and the General Data Protection Regulation (GDPR), ensuring the highest standards of data security, transparency, and long-term sustainability, while contributing to the development of a globally connected regional genomics ecosystem.